Refining RNA-Seq Transcriptome Profiles with Transcript-Specific Minimal-Shared Regions
Accurate transcript quantification remains a critical challenge in RNA sequencing (RNA-seq) due to ambiguities in read assignment caused by shared regions among transcripts. Beyond shared exons among homologous isoforms, we identified the widespread presence of extensive undefined shared regions-overlapping sequences common to exons or transcripts of heterologous genes-across diverse species,…
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