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Povorcitinib for nonsegmental vitiligo: two randomized, controlled, phase 3 STOP-V trials

Nature Medicine, Published online: 02 November 2026; doi:10.1038/s41591-026-04739-2 In the STOP-V1 and STOP-V2 trials, povorcitinib (an oral JAK1 inhibitor) was superior to placebo in improvement in F-VASI75 score in individuals with nonsegmental vitiligo.

We haven't written up this one. Nature Medicine has the full story — the link below goes straight to it.

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Diagnosing dark sprite edges: a practical alpha compositing check

A transparent character can look correct in an image viewer yet acquire a dark fringe in a game. Before changing the artwork, check whether the image data and renderer agree about alpha representation…

  • Verify alpha representation between image data and renderer to prevent darkened assets.
  • Compare partly transparent test image over black, white, and saturated backgrounds to isolate cause.

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