Pharmacological activation of mitophagy prevents calcific aortic valve disease by targeting dysregulated mitochondrial-to-nuclear communication
Abstract Background and Aims: Calcific aortic valve disease (CAVD) lacks pharmacologic therapy. Mitophagy impairment contributes to various degenerative diseases, but whether it occurs in calcified aortic valves and during human valvular interstitial cell (hVIC) osteogenic differentiation remains unknown. We therefore investigated the role of mitophagy in CAVD and whether its pharmacological…
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