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Neoadjuvant botensilimab with or without balstilimab in pMMR and dMMR colon cancer: the phase 2 UNICORN trial

Nature Medicine, Published online: 02 November 2026; doi:10.1038/s41591-026-04710-1 In the phase 2 UNICORN trial, a short course of neoadjuvant botensilimab and balstilimab achieved the primary endpoint of pathological major response rate in patients with pMMR or dMMR colon cancer.

We haven't written up this one. Nature Medicine has the full story — the link below goes straight to it.

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Diagnosing dark sprite edges: a practical alpha compositing check

A transparent character can look correct in an image viewer yet acquire a dark fringe in a game. Before changing the artwork, check whether the image data and renderer agree about alpha representation…

  • Verify alpha representation between image data and renderer to prevent darkened assets.
  • Compare partly transparent test image over black, white, and saturated backgrounds to isolate cause.

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