How Well Does Structural MRI Classify Autism? A Leakage-Free, Site-Aware and Externally Validated Machine-Learning Evaluation in Two ABIDE Cohorts
Background: Many studies report high accuracy for classifying autism spectrum disorder (ASD) from structural MRI, but small samples, single train-test splits, site effects and information leakage can inflate performance. We evaluated how well brain morphometry distinguishes autistic from typically developing (TD) individuals under rigorous, leakage-free validation. Methods: FreeSurfer-derived…
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