Filament assembly confers the mechanical resilience of the IFI16 restrictosome
Interferon-inducible protein 16 (IFI16) is a mammalian innate immune sensor composed of a filament-forming pyrin domain (PYD) followed by tandem HIN200 domains that bind nucleic acids. First recognized as a major regulator of inflammatory responses against cytosolic double-stranded (ds)DNA, IFI16 filaments have been implicated in several key mechanical processes involving both host and pathogens,…
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