Fentanyl and fentanyl-xylazine co-exposure influence mitochondrial transcriptional programs in human trophoblasts
Introduction: Illicit fentanyl exposure during pregnancy is associated with adverse outcomes. Yet its direct effects and their underlying molecular mechanisms in human trophoblasts remain largely unknown. Xylazine and medetomidine, two [a]2-adrenergic agonists, were recently detected as adulterants in illicit fentanyl-containing products, and have been linked to worsened clinical outcomes.…
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