De novo design of mini-proteins as specific binders to PACAP-38, a key mediator of migraine
Pituitary adenylate cyclase-activating peptide 38 (PACAP-38) is a vasoactive peptide that is attracting attention as a potential target for next-generation migraine treatments. Antibodies against PACAP-38 have recently shown promising results as a ligand trap medicine in clinical trials. In this study, we investigated the de novo design of miniproteins to evaluate the potential for developing a…
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