Integrative multi-omics re-analysis of public sequencing and metabolomics repositories defines the mucosal immune and metabolic landscape of Helicobacter pylori infection and supports CagW as a rational mRNA-LNP vaccine antigen
Background. Helicobacter pylori colonises 40-45% of the global population, is a WHO Group I carcinogen, and is increasingly hard to eradicate amid rising resistance; no vaccine is licensed. CagW, a VirB6-family cagPAI component, has been advanced as a DNA-vaccine antigen that protects mice; a codon-optimised CagW-Fc mRNA in lipid nanoparticles (mRNA-LNP) is a candidate antigen design intended to…
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