Gastric resection and restriction yield distinct neuroendocrine and metabolic outcomes in obese mice
Whether the metabolic benefits of sleeve gastrectomy arise from gastric restriction alone or also depend on tissue resection remains unclear. We compared sleeve gastrectomy (SG) with a surgical sleeve gastroplasty (GP) model that restricts the stomach without removing tissue. Diet-induced obese male C57BL mice were randomized to SG, GP, or sham surgery and evaluated over six weeks for energy…
Two types of gastric surgeries were examined in obese mice to determine their respective neuroendocrine and metabolic effects. Sleeve gastrectomy (SG) involved the complete removal of a portion of the stomach, while gastric sleeve gastroplasty (GP) restricted stomach size without tissue removal. Despite similar weight loss (12% and 11% respectively), SG and GP showed differences in meal patterns, with SG resulting in smaller, more frequent meals.
Both surgeries improved glucose regulation, with SG achieving greater improvement. SG also led to reduced levels of hepatic triglycerides and branched chain amino acids in the bloodstream. Additionally, SG caused a decrease in expression of POMC, while NPY and AgRP expressions were decreased specifically after SG surgery. Hormonally, SG led to higher fasting levels of GLP1 and PYY, lower ghrelin levels, and a greater glucose-stimulated response in gut and pancreatic hormones.
These distinct metabolic and neuroendocrine changes post-SG suggest that gastric resection, rather than just restriction, contributes to the overall benefits of sleeve gastrectomy.
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