CDKL5 deficiency alters cell subtype-specific molecular programmes and intercellular signalling in the mouse hippocampus
CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental condition characterised by epilepsy, intellectual disability, and motor dysfunction. Loss of CDKL5 leads to altered synapse development, excitatory-inhibitory imbalances and glial changes, but the underlying molecular mechanisms remain incompletely understood, particularly at the level of individual brain cell subtypes. Here, we…
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