Whole-genome sequencing reveals tumor T-cell infiltration associated with immunotherapy outcomes
Background: Whole-genome sequencing (WGS) enables comprehensive assessment of genomic biomarkers for precision oncology within a single assay. Recent studies have shown that WGS can also reveal features of the tumor immune microenvironment, including T- and B-cell infiltration1. Here, we evaluated whether T-cell receptor reconstruction from WGS provides a measure of tumor T-cell infiltration that…
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