Pan-pediatric brain tumor microRNA networks define immune microenvironment states and responses to CAR T-cell therapy
Pediatric central nervous system (CNS) tumors remain a leading cause of cancer-related mortality in children, yet molecular programs that shape their immune microenvironments and response to immunotherapy remain poorly defined. Because microRNAs (miRNAs) coordinately regulate gene expression across multiple pathways, we hypothesized that miRNA programs may capture broader immune states than…
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