Supervised 3D Virtual Fluorescence and Pseudo-H&E Staining of Fresh Bulk Tissues via Multimodal qOBM and Fluorescence Microscopy
We introduce a multimodal microscope that combines quantitative oblique back-illumination microscopy (qOBM) with wide-field epi-fluorescence deconvolution microscopy to acquire intrinsically co-registered phase and fluorescence volumes of fresh, bulk tissue. Using paired qOBM phase and DAPI fluorescence images of fresh ex vivo mouse brain tissue, we train a supervised conditional generative…
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