Multiparametric MRI and imaging transcriptomics reveal brain-wide changes in GD3 synthase deficiency
Using an integrative imaging-transcriptomic approach that highlights the molecular complexity underlying neuroimaging phenotypes, we investigated a mouse model with disrupted ganglioside synthesis: the GD3 synthase-deficient mouse (St8sia1-null; GD3S KO). Gangliosides are membrane glycosphingolipids essential for brain development, neural plasticity and organisation of membrane lipid rafts. We…
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