DNA sequence sets the destination of spontaneous epimutations in plants
Plant genomes gain and lose cytosine methylation spontaneously, far faster than DNA mutates, and these epimutations are inherited. The genome is thought to set a steady state around which methylation fluctuates. Here we show that this steady state, the set point, is written in the DNA of each CG site: REED, a deep-learning model trained on one methylome, reads it. In pedigrees of seven…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
