Development and design rules for a modular human peptide-tag adaptor CAR T cell system
CAR T cells are highly effective in haematological malignancies, but limited post-infusion control and tumour antigen heterogeneity remain major challenges. Modular CAR systems address these limitations using interchangeable adaptor molecules (AM) to control CAR T cell engagement and redirect targeting toward different antigens, yet the design principles underlying effective modular function…
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