Automated DNA-Encoded Library Synthesis on Magnetic Anion Exchange Resin
DNA-encoded libraries (DELs) access vast chemical spaces for drug discovery, but split-and-pool DEL synthesis remains the sole and very manual portion of the DEL workflow. Here, we automate DEL construction using diethylaminoethyl-functionalized weak anion exchange (WAX) magnetic resin and a KingFisher Apex particle-handling instrument. DNA encoding occurs in solution, followed by selective…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
