An organotypic hippocampo-prefrontal co-culture model for studying long-range connectivity and circuit plasticity
The hippocampal projection to the medial prefrontal cortex (mPFC) is a key component of brain networks involved in cognition and emotion. Here, we establish and validate an organotypic entorhino-hippocampo-prefrontal co-culture model that enables experimental investigation of long-range circuit connectivity and plasticity under controlled in vitro conditions. Anatomical tracing, viral labeling,…
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