Towards VDAC pharmacology: Developing small-peptide channel inhibitors inspired by nature
The Voltage-Dependent Anion Channel (VDAC) forms a unique pathway across the mitochondrial outer membrane for small ions and water-soluble metabolites, such as ATP and ADP. Despite VDAC's involvement in both normal regulation of respiration and in a wide variety of mitochondria-associated pathologies, there are, surprisingly, no known FDA-approved pharmacological agents targeting VDAC. Earlier,…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
