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A study examining the effects of childhood trauma on cortical thickness in individuals with bipolar disorder found no significant differences after accounting for multiple comparisons. Bipolar disorder with psychosis (BDP) did show greater thickness in the superior temporal region compared to bipolar disorder without psychosis (BD), while sexual abuse was associated with reduced temporal thickness.
The researchers explored potential trauma-by-diagnosis interactions, but these did not meet the necessary criteria for significance. Medication class and illness duration did not have a notable impact on cortical thickness. The findings, considered preliminary, warrant further investigation in larger samples to confirm any potential connections between childhood trauma subtypes and cortical thickness in bipolar disorder.
Written by urgent.news from bioRxiv's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
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