Alternative splicing use ratio is not conserved between human and mouse immune cells
Most human genes have mouse orthologs. However, orthology at the level of exons and alternative splicing events is not well defined, and the use of alternative splicing events in immune cell types has not been compared between human and mouse. We mapped exons and alternative splicing events between human and mouse. Based on this mapping, the use ratio of orthologous alternative splicing events…
When comparing human and mouse immune cells, the proportion of alternative splicing events that are conserved is not uniform. Of the 1,823 human-mouse orthologous alternative splicing events observed in five tested immune cell types, a majority (62-67%) demonstrated a significant disparity in their usage between the two species.
Only a small fraction (21-25%) maintained the same ratio of usage. This study uncovers a mix of conserved and divergent patterns in alternative splicing regulation, showcasing the intricate evolution of this process in human and mouse immune cell types. By linking exon orthology with actual splicing patterns, researchers have constructed a functional framework for investigating the evolution of splicing ratios in mammals, going beyond mere transcript annotations.
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