Colts vs. Titans: 5 things to know plus a prediction

The Indianapolis Colts return to their home field in Week 6, seeking a crucial victory against their division rivals, the Tennessee Titans. While both teams have faced each other numerous times before, each year brings unique dynamics to their matchups. To gain insight into the Titans' performance this season, Mark Mihalko of Titans Wire answered several questions.

Cam Ward has struggled this season, showing inconsistent performance compared to his impressive rookie year. The Titans' offensive game has been lacking, particularly with the absence of a strong running game that proved effective at the end of 2025. The offensive line, excluding Dan Moore, has been a surprising bright spot, with right tackle JC Latham excelling and looking like the player Tennessee selected in the 2024 draft.

However, the loss of right guard Fernando Carmona and his top backup, Jackson Slater, have disrupted continuity, with veteran Atonio Mafi stepping in to fill the gaps.

The Titans' biggest challenges lie in their lack of offensive identity and inconsistent cornerback play on defense. Offensively, their performance remains inconsistent, and unpredictable play calling has hurt their chances, particularly in the first half of games. Despite investing in the cornerback position during the offseason, the results have been underwhelming, with starter Alontae Taylor and Cor’Dale Flott struggling throughout the season.

One under-the-radar player to watch is safety Tony Adams. Often overlooked, Adams has stepped up with quality contributions to the defense. Against the Houston Texans in Week 5, he started with Amani Hooker in concussion protocol and is set to return for another start against the Colts. His understanding of the defensive scheme and ability to make plays have made him a valuable asset. With his leadership, the Titans' defense could better slow down high-caliber opponents like Jonathan Taylor.