Turning Process Understanding Into Control of Lipid Nanoparticles
Splitting lipid nanoparticle manufacturing into multiple mixing steps can help better control the size, shape, and stability of particles, with the aim of improving product quality during commercial-scale production. The post Turning Process Understanding Into Control of Lipid Nanoparticles appeared first on GEN - Genetic Engineering and Biotechnology News .
Bizon Labs, an MIT spin-off, seeks to improve the scalability of lipid nanoparticles (LNP) production. The company's name derives from bison, symbolizing their determination to tackle the challenges of LNP formulation improvement. Postdoctoral associate Cedric Devos explains that their focus is on physically optimizing LNP delivery through process adaptation, rather than solely relying on chemical optimization.
Their goal is to attain precise control over LNP attributes, enabling novel biological applications. The team has developed process innovations to better control LNP size and morphology, which have been challenging to achieve using conventional techniques. By segmenting the traditional mixing process into multiple steps, they can better understand and replicate LNP production processes at various scales.
This approach allows them to manipulate LNP shape, enhancing product stability for long-term storage. The team also aims to optimize therapeutic cargo, improve mechanistic understanding of the LNP process, and enhance downstream processing, such as purification. Devos emphasizes that their work is ongoing, with further control and advancements still to be achieved.
Written by urgent.news from GEN Biotechnology's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
