Researchers use AI to design proteins that cut up other proteins
AI design tools make proteins that break bonds that are stable for hundreds of years.
Proteins, long chains of amino acids bonded by peptide bonds, are short-lived in Earth's environment, often being broken down by specialized protease enzymes. Researchers have now used AI-based protein design tools to design new enzymes that can cut proteins more efficiently. By replacing the entire rest of the protein but keeping the catalytic core of two types of protease, the researchers created new enzymes capable of cutting specific proteins in half.
These enzymes were tested and found to be effective in cutting proteins associated with neurological diseases.
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- Researchers use AI to design proteins that cut up other proteins arstechnica.com
