No two are the same: Identification and characterization of novel hyperactive PrfA* variants in Listeria monocytogenes
The virulence potential of the human pathogen Listeria monocytogenes is primarily controlled by the master virulence regulator PrfA. PrfA activity is tightly regulated to prevent virulence gene expression outside the host, while enabling their rapid induction upon host cell entry. One mechanism controlling PrfA activity is the sugar-dependent inhibition. Readily metabolizable sugars, such as…
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