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Population-scale reconstruction of menopause dynamics reveals a physiological cliff at the final menstrual period

Nature Medicine, Published online: 12 October 2026; doi:10.1038/s41591-026-04614-0 By using a novel computational framework, a cross-sectional analysis on laboratory data from two independent cohorts reveals that the final menstrual period marks an abrupt, multisystem physiological shift, with sex hormone changes beginning more than 10 years before menopause onset.

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