Unstable Heteroresistance as a Stepping Stone to Stable Resistance via Compensatory Mutations
Antibiotic heteroresistance, a trait in which a drug-susceptible population harbors a rare resistant subpopulation, has been presented as an unstable intermediate state on the way to classic stable antibiotic resistance. However, the timescales and pathways under which this could occur has not been examined. Extending a recombination-based model of copy- heteroresistance to include compensatory…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
