Systematic mapping of enhancers, silencers, and topological elements with prime editing deletion screens
Noncoding regulatory elements in the human genome can control gene expression through distinct mechanisms, including acting as enhancers, silencers, or topological elements. However, we lack tools to identify all such classes systematically and quantify their effects on gene expression in an endogenous genomic context. Here we develop Swap-seq, a method that combines pooled twin prime editing…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
