Senescence-induced Spatio-temporal Re-organization of the Nuclear Lamina Dynamic Landscape at Single-molecule Level in Live Human RPE Cells
A defining hallmark of cellular senescence is the extensive remodeling of the nuclear lamina (NL) in both structure, composition, and its interactions with lamina-associated genomic domains. However, how such senescence-induced changes could quantitatively impact the spatio-temporal dynamics of NL interactions at the single-molecule level remain poorly understood. Herein, using human retinal…
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