Combining AlphaFold 3 with microscale thermophoresis for aptamer optimisation
Although use of AI-based tools has gained ground in molecular biology research, their reliability remains a matter of debate. Here, we combined AlphaFold 3 modelling with microscale thermophoresis to investigate the interactions between glucan-binding protein C and the biofilm-inhibiting aptamer and its five derivatives. Structural modelling identified a binding motif on the aptamer and suggested…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
