A Multilayer Human Skin Diseasome Links Molecular Architecture, Clinical Co-occurrence, and Drug-Reversal Signatures
Abstract Background: Immune-mediated skin diseases frequently co-occur, but the molecular architecture connecting clinically distinct disorders, and the extent to which molecular proximity predicts shared therapeutic opportunity, remain incompletely defined. We constructed a multilayer skin diseasome integrating transcriptomic overlap, pathway enrichment, protein-interactome topology, curated…
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