Pumilio proteins license viral noncoding RNA engagement with target mRNAs
Noncoding RNAs commonly rely on RNA-binding proteins (RBPs) to execute their regulatory functions, but whether RBPs can instead facilitate target recognition by noncoding RNAs is poorly understood. Here, we identify a non-canonical function for Pumilio proteins PUM1 and PUM2 in gene regulation as cofactors of the viral small nuclear RNAs HSUR1 and HSUR2 encoded by Herpesvirus saimiri. HSUR1 and…
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