WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state transitions
Chromatin mobility, the exploration of 3D conformations by the chromatin fibre, is implicated in transcription and DNA repair, and is thought to decrease progressively as cells differentiate. Here, combining live-cell 3D single-nucleosome tracking with genomic approaches, we show that chromatin mobility instead changes in a cell-type-specific manner, increasing as pluripotent cells acquire…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
