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Polyhydroxyalkanoate carbonosomes impact the activity and viability of growth-arrested Pseudomonas aeruginosa during nutrient fluctuations and tobramycin exposure

The opportunistic pathogen Pseudomonas aeruginosa can store carbon by polymerizing (R)-3-hydroxy fatty acids into polyhydroxyalkanoates (PHA) and forming large intracellular carbonosomes. These structures primarily function as stores of excess carbon that can be employed during nutrient imbalances, though they have been increasingly reported to have secondary functions in stress responses. A…

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