Integrating single-cell and bulk transcriptomes identifies neuronal heat-stress-associated candidate genes in a reef-building coral
Cell-type-specific molecular responses are obscured in bulk RNA sequencing, whereas generating matched single-cell datasets across environmental conditions remains costly and technically challenging, particularly in non-model organisms. Here, we present a workflow that integrates existing bulk and single-cell RNA-seq resources to prioritize cell-type-associated environmental-response genes. We…
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