Axonal dysfunction precedes axonal degeneration in a mouse model of progressive parkinsonism
Axons of substantia nigra dopaminergic neurons "die back" in Parkinson's disease (PD), exhibiting early degeneration relative to cell bodies, a key feature also observed in PD models. A critical step towards understanding the process of axonal neurodegeneration is to determine the physiological properties of dopaminergic axons that are altered during the early stages of cellular dysfunction.…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
