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A microbiota-dependent gut bile acid axis links germline mutant p53 to distal tumour growth.

The gut microbiome can influence cancer development, but its contribution to cancer predisposition in Li-Fraumeni Syndrome (LFS) remains poorly understood. Here, we investigated whether germline mutant p53 alters the intestinal environment using Trp53R172H/+ mice. Tumour-naive mutant mice exhibited increased intestinal permeability and a pro-inflammatory colonic phenotype, including elevated…

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

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