First successful primate transplant of human pituitary tissue boosts cortisol levels
Researchers in Japan have transplanted pituitary tissue grown from human stem cells into a primate whose pituitary gland had been surgically removed, successfully restoring critical hormone signals. Led by researchers from Nagoya University in Japan, the team showed that the same method worked in mice over a longer period.
Researchers in Japan have successfully transplanted lab-grown human pituitary tissue into a primate, restoring crucial hormone signals for the first time. The team from Nagoya University transplanted pituitary organoids, grown from human stem cells, into a macaque monkey whose gland had been removed. The organoids, which produce adrenocorticotropic hormone (ACTH), elevated cortisol levels in the primate's blood for six weeks.
ACTH controls cortisol production, which is vital for managing stress, blood pressure, and blood sugar. Without sufficient ACTH, hypopituitarism can occur, leading to dangerous complications. Daily hormone pills cannot fully replicate the body's natural cortisol fluctuations, putting patients at risk of sudden death. While the transplant lasted six weeks, no tumors or abnormal cell growth were observed.
The researchers plan to refine their technique to enhance graft longevity and explore safer immune-suppression methods for future human trials.
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