When does post-ingestive dopamine signaling occur in humans?
The post-ingestive dopamine response is an integral determinant of subsequent eating behavior in animals yet measurement of the post-ingestive response to nutrients in humans has been elusive when assessed in the early post-ingestive period (30 minutes postprandially). We conducted secondary analysis comparing dopamine D2 receptor binding potential (D2BP) measured using [18F]fallypride positron…
The post-ingestive dopamine response plays a crucial role in shaping subsequent eating behavior in animals. However, assessing this response to nutrients in humans, particularly in the early post-ingestive period (30 minutes after a meal), has been challenging. Researchers conducted a secondary analysis to compare dopamine D2 receptor binding potential (D2BP) using [18F]fallypride positron emission tomography in two groups of participants who underwent controlled feeding.
The study included 57 participants (66.7% female) who had fasted overnight and 43 participants (48.8% female) who had consumed a standardized meal representing 20% of their energy requirements. The results revealed that the 2-hour postprandial cohort exhibited significantly reduced whole striatal D2BP compared to the fasted group (p < .001).
This suggests that post-ingestive dopamine signaling occurs within the early post-prandial period, specifically within the first 30 minutes after a meal, and plays a significant role in modulating eating behavior in humans.
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