Nucleolar buffering of lamina-associated heterochromatin restrains Progerin-induced ageing programs
Nucleolar enlargement is a conserved hallmark of physiological and premature ageing, including Hutchinson-Gilford Progeria Syndrome (HGPS), a disorder caused by LMNA mutations that produce Progerin and profoundly disrupt nuclear architecture. Although both the nuclear lamina and nucleolus organize repressive chromatin, how nucleolar remodelling contributes to genome reorganization during ageing…
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