Cryo-EM structures of insect IRs reveal the structural adaptations of a glutamate receptor ancestor for environmental sensing
Ionotropic receptors (IRs) are an ancient, massively expanded family of sensory ion channels that mediate chemical, thermal, and hygrosensory detection across invertebrates. Derived from synaptic ionotropic glutamate receptors (iGluRs), IRs achieve this diverse tuning by assembling conserved co-receptor subunits with highly divergent tuning subunits into obligate heteromers. To understand how…
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