ProxiNet transfers spatially learned cellular proximity to dissociated single-cell transcriptomes

Spatial transcriptomics reveals cellular organization within intact tissues, whereas dissociated single-cell RNA sequencing provides broad transcriptomic coverage but loses information about cellular proximity and neighborhood structure. Here, we developed ProxiNet, a spatially supervised framework that learns transcriptomic signatures of pairwise cellular proximity from spatial reference…

biorxiv.org ·23h ago

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