MAFA drives pancreatic islet maturation through coordination of cell growth, metabolic maturation, and resilience to stress.
Stem cell-derived islets (SC-islets) are a promising source for replacing the loss of insulin-secreting {beta} cells in insulin-dependent diabetes patients, but compared to their primary human counter parts, SC-islets are considered functionally immature and do not immediately regulate blood glucose after transplantation. To better understand the molecular underpinnings of {beta} cell maturation,…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
