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Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1 By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.

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