Factors underlying creativity show distinct genetic architecture and genetic correlations with psychiatric disorders

While creativity is widely recognized as multifaceted, genome-wide association studies have largely focused on individual measures. Here, we used genomic structural equation modeling of six creativity-related GWASs and identified two latent genetic factors: a general factor and an artistic factor, with 22 and 13 genome-wide significant loci, respectively, nine of which are novel. The general…

biorxiv.org ·1d ago

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