Engineering robust cardiomyocyte differentiation from iPSCs through WNT-mediated process window expansion

Lack of robustness and high variability in cardiomyocyte (CM) differentiation from human induced pluripotent stem cells (hiPSCs) remain critical challenges for cardiac regenerative medicine and biological research. Guided by developmental principles of lineage specification, we investigated whether early WNT inhibition could expand the process window of CM differentiation and thereby improve…

biorxiv.org ·13h ago

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