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Bridging the gap between omics and structural data: A framework for interpreting protein-RNA interaction specificity

Protein-RNA interactions play a central role in many cellular processes, such as gene regulation, protein synthesis and viral infections. Although a few thousand protein-RNA complexes have been structurally characterized, they represent only a small fraction of all interactions. This lack of experimental data limits the ability of deep-learning based approaches such as AlphaFold3 to predict…

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