Viral Strategies for In Vivo Optogenetic Stimulation of Purkinje Cell Terminals and Electrophysiological Characterization of Downstream Cerebellar Nuclear Activity in Mice
The cerebellar cortex regulates motor and cognitive function through its sole output neurons, the Purkinje cells (PCs), which inhibit downstream targets, yet precise manipulation of PC activity in vivo remains technically challenging. Here, we describe two viral strategies with differing cell-type specificities for in vivo optogenetic control of PCs and functional assessment of neural activity in…
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