Spinal V2a neurons support locomotor propagation via long-range connectivity
The spinal cord contains a diverse set of neurons whose activity is vital for motor control. Despite the importance of these spinal interneurons in network models of locomotion, their circuitry remains poorly understood. We quantified the synaptic output of V2a (vsx2+) interneurons, a glutamatergic population implicated in control of locomotor speed, rhythm generation, and recovery from injury,…
Zebrafish larvae serve as a model for studying spinal cord neurons. Specifically, glutamatergic V2a interneurons have been found to play a key role in controlling locomotion. Initial models suggested these cells promote recurrent local excitation. However, new research reveals a surprising finding. The majority of V2a neurons' monosynaptic output extends to motor and premotor targets at long distances, rather than simply activating nearby cells.
This long-range connectivity stands in contrast to previous assumptions about the role of V2a neurons. When V2a neurons are lost, the ability to transmit locomotion signals over long distances is impaired. Fortunately, this does not affect the neurons' ability to generate rhythmic movements locally. The study concludes that V2a neurons are essential for long-range coordination within the spinal cord.
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